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Articles
Assessing Microsoft R Open for implementation in a production environment in the clinical industry

25 Feb 2021

Christos Stylianou, Ph.D
Articles
Differences between the three candidate COVID-19 vaccines

December 17, 2020

Christos Stylianou, Ph.D and Elena Hadjicosta, Ph.D
Articles
Διαφορές ανάμεσα στα τρία προτεινόμενα εμβόλια για τον ιό COVID-19

Δεκέμβριος 17, 2020

Χρίστος Στυλιανού, Ph.D and Έλενα Χατζηκώστα, Ph.D
Articles
Using SQL for cross-platform statistical programming (for SAS, R and more)

03 December 2020

Christos Stylianou, Ph.D
Articles
Innovative prolonged‑release oral alkalising formulation allowing sustained urine pH increase

15 September 2020

Innovative prolonged‑release oral alkalising formulation allowing sustained urine pH increase with twice daily administration: randomised trial in healthy adults
C. Guittet, C. Roussel‑Maupetit, M. A. Manso‑Silván, F. Guillaumin, F. Vandenhende & L. A. Granier
Articles
Efficacy and safety of an innovative prolonged-release combination drug in patients with distal renal tubular acidosis: an open-label comparative trial versus standard of care treatments

26 July 2020

Distal renal tubular acidosis (dRTA), due to impaired acid secretion in the urine, can lead to severe long-term consequences. Standard of care (SoC) oral alkalizers, requiring several daily intakes, are currently used to restore normal plasma bicarbonate levels. A new prolonged-release formulation, ADV7103, has been developed to achieve a sustained effect with an improved dosing scheme.
Aurélia Bertholet-Thomas, Catherine Guittet, Maria A. Manso-Silván, Arnaud Castang, Véronique Baudouin, Mathilde Cailliez, Massimo Di Maio, Olivia Gillion-Boyer, Emilija Golubovic, Jérôme Harambat, Alexandre Klein, Bertrand Knebelmann, François Nobili, Robert Novo, Ludmila Podracka, Gwenaëlle Roussey-Kesler, Christos Stylianou & Luc-André Granier
Articles
Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial

27 April 2020

Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation).
Lucy Brazil, Angela L Swampillai, Ka Man Mak, Darren Edwards, Pavlina Mesiri, Laura Clifton-Hadley, Richard Shaffer, Joanne Lewis, Colin Watts, Sarah Jeffries, Pinelopi Gkogkou, Anthony J Chalmers, Naomi L Fersht, Allan Hackshaw, Susan C Short
Articles
The Effect of Carryover in the Estimation of Model Adjusted Means in Cross-Over Studies

March 2020

Carryover effects constitute a potential issue when using the crossover design. Multiple methods exist, both for modelling the carryover effect, and predicting adjusted means from these models. In this paper, we investigated the reliability of the prediction methods for estimating the model adjusted means and their differences, using a simulation study.
Christos Stylianou, Ph.D
Articles
Executing R from SAS

05 March 2020

Statistical reporting primarily performed using SAS, wanted to execute an analysis only available currently in R
Christos Stylianou, Ph.D
Articles
Evaluating the Potential of Drug Combinations

14 January 2020

Francois Vandenhende, Ph.D
Articles
Insulin exposure mitigates the increase of arterial stifness in patients with type 2 diabetes and albuminuria: an exploratory analysis

16 April 2019

Acta Diabetologica, pp1-7
Daniel Gordin, Markku Saraheimo, Jaana Tuomikangas, Aino Soro‑Paavonen, Carol Forsblom, Karri Paavonen4, Birgit Steckel‑Hamann, Valma Harjutsalo, Loizos Nicolaou, Imre Pavo, Veikko Koivisto, Per‑Henrik Groop
Articles
A free tool to generate automatically user documentation for SAS macro libraries

November 2018

PhUSE EU Connect 2018, Frankfurt, Germany
Renos Kakoullis, Julien Vanwinsberghe, Loizos Nicolaou
Articles
Bayesian adaptive designs in single ascending dose trials in healthy volunteers 2015

April 16 2015

David Guédé (ClinBAY).
Posters
Bayesian adaptive designs for phase 1 studies in healthy volunteers

April 14-17 2015

Symposium on early phase dose finding methodology.
David Guédé (ClinBAY), Dr. Francois Vandenhende (ClinBAY), Dr. O’Quigley John.
Articles
Bayesian adaptive designs in single ascending dose trials in healthy volunteers 2014

February 17 2014

Br J Clin Pharmacol. doi: 10.1111/bcp.12344
Guédé D, Reigner B, Vandenhende F, Derks M, Beyer U, Jordan P, Worth E, Diack C, Frey N, Peck R.
Articles
Long term inhibition of IL-17A with secukinumab reduces spinal inflammation but has no influence on fatty lesions as assessed by magnetic resonance imaging in patients with ankylosing spondylitis

June 12-15 2013

EULAR 2013 congress, Madrid, Spain.
X. Baraliakos, J. Braun, D. Laurent, D. Baeten, D. van der Heijde, J. Sieper, P. Emery, I. McInnes, J. van Laar, R. Landewe, P. Wordsworth, J. Wollenhaupt, H. Kellner, A. Wright, F. Vandenhende, K. Radford, B. Borah, W. Hueber.
Articles
Using Bonferroni, BIC and AIC to assess evidence for alternative biological pathways: covariate selection for the multilevel Embryo-Uterus model

June 6 2013

BMC Med Res Methodol. 13:73. doi: 10.1186/1471-2288-13-73
Christos Stylianou, Andrew Pickles and Stephen A Roberts.
Posters
Statistical evaluation of QT/QTc prolongation and proarrhythmic potential for non-antiarrhythmic drugs

13-15 May 2013

36th Annual Conference of PSI. Glasgow, UK.
Christos Stylianou.
Presentations
Application of Bayesian Statistics in early development studies

April 11-12 2013

Club Phase I, Nice Sophia Antipolis, France.
Francois Vandenhende (ClinBAY), Patricia Sanwald Ducray (Roche).
Presentations
Assessment of Brain Kappa Opioid Receptor Occupancy after Single Oral Doses of LY2456302 as Measured by PET with the Radioligand LY2879788 in Healthy Subjects

December 2-6 2012

American College of Neuropsychopharmacology, 51st annual meeting, Hollywood, USA.
Johannes Tauscher, Francois Vandenhende, Jennifer Witcher, Mohini Ranganathan, Ming-Qiang Zheng, Mika Naganawa, Henry Huang, Alexander Neumeister, Richard Carson.
Articles
The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice

November 9 2012

Vet Microbiol. 2012 160(1-2):141-50.
Demon D, Ludwig C, Breyne K, Guédé D, Dörner JC, Froyman R, Meyer E.
Presentations
Using a free syntax-colored SAS Log Viewer to bookmark important messages, filter them, and more!

October 14-17 2012

PhUSE Conference 2012, Budapest, Hungary.
Julien Vanwinsberghe and Francois Vandenhende.
Presentations
SAS macro package to automate coding graphs with ClinXport

October 14-17 2012

PhUSE Conference 2012, Budapest, Hungary.
Philippe Remusat and Francois Vandenhende.
Presentations
Automation of clinical trial reporting: from shells to TFL outputs without a single line of SAS® code

March 19-20 2012

FDA/PhUSE Annual Computational Science Symposium, Silver Spring Civic Center, Silver Spring, MD.
Francois Vandenhende, Julien Vanwinsberghe and Philippe Remusat.
Presentations
Nouveaux designs, approche Bayésienne en phase précoce

February 2 2012

Journée du Club Phase 1, Paris, France.
Bruno Reignier and Francois Vandenhende.
Presentations
ClinXPORT a software to streamline the analysis and reporting of clinical trials with SAS®

October 10-12 2011

Phuse 2011, Brighton, UK.
Julien Vanwinsberghe, Philippe Remusat, Francois Vandenhende.
Articles
ClinXPORT: a software to streamline the analysis and reporting of clinical trials with SAS®

October 10-12 2011

Phuse 2011, Brighton, UK.
Julien Vanwinsberghe, Philippe Remusat, Francois Vandenhende.
Articles
The effects of a single dose administration of SAM-531, a 5-HT6 antagonist, on sleep electroencephalogram (EEG) and quantitative wake EEG (qEEG) in healthy subjects

July 2010

Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 2010 July Volume 6, Issue 4, Supplement , Page S510.
Susan J. Baird-Bellaire, Hong Wan, Francois Vandenhende, Anna Plotka, Nagaraju Poola, Jeffrey Paul, Philippe Danjou, Stephan Chalon.
Articles
An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers

April-March 2010

Clin Neuropharmacol 33(2):55-60
Brooks DJ, Papapetropoulos S, Vandenhende F, Tomic D, He P, Coppell A, O’Neill G.
Articles
Development of the 2nd Generation Neurokinin-1 Antagonist LY686017 for Social Anxiety Disorder

February 2010

Eur. Neuropsychopharmacol 20(2):80-7.
Johannes Tauscher, William Kielbasa, Smriti Iyengar, Francois Vandenhende, Xiaomei Peng, David Mozley, Donald R. Gehlert, Gerard Marek.
Articles
Pharmacokinetic parameters estimation using adaptive Bayesian P-splines models

April-June 2009

Pharm Stat. 8(2):98-112.
Jullion A, Lambert P, Beck B, Vandenhende F.
Presentations
Adaptive designs in clinical trials

March 3 2009

UCL.
Francois Vandenhende.
Posters
Bayesian dose selection strategy in biomarker trials

January 26-28 2009

Bayesian Biostatistics Conference: Houston, Texas.
Francois Vandenhende.
Presentations
Adaptive Bayesian Methods for Biomarker Trials: Application to Brain Imaging

November 18 2008

PSI Biomarker in Early Phase, London, UK
Francois Vandenhende.
Articles
Decimaker: A statistical software using R, Microsoft .NET, R (D)COM Server and graphical libraries

October 12-15 2008

PhUSE Paper AD05. Manchester, UK.
Julien Vanwinsberghe, Francois Vandenhende.
Articles
Bayesian hierarchical modeling of receptor occupancy in PET trials

2008

J Biopharm Stat. 18 (2):256-72.
F. Vandenhende, D. Renard, Y. Nie, A. Kumar, J. Miller, J. Tauscher, J. Witcher, Y., Zhou, and D. Wong.
Presentations
Decimaker: software for adaptive design and Bayesian decision analysis

February 6-7 2008

SMi adaptive design conference, London, UK.
Francois Vandenhende and Julien Vanwinsberghe.
Presentations
Decimaker: software for adaptive design and Bayesian decision analysis

January 30 - February 1 2008

Bayesian Biostatistics conference, Houston, TX, USA.
Francois Vandenhende and Julien Vanwinsberghe.
Articles
Imaging the norepinephrine transporter with positron emission tomography:initial human studies with (S,S)-[18F]FMeNER-D2

January 2008

European Journal of Nuclear Medicine and Molecular Imaging 35(1):153-7
Takano A, Gulyás B, Varrone A, Karlsson P, Schou M, Airaksinen AJ, Vandenhende F, Tauscher J, Halldin C.
Articles
Joint detection of influential biomarkers and optimal dose-response model using penalties

November 30 2007

Statistics in Medicine 26(27):4876-88.
François Vandenhende, Paul Eilers, Edouard Ledent, Didier Renard and Fabian Tibaldi.
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